Pill of the Month

February 2008- Lisinopril Oral

Brand Names: Prinivil, Zestril

What it is: This drug is predominantly used in treating patients who suffer form high blood pressure, also known as hypertension. Another use of this medication is on those patients who have suffered an acute heart attack or in conjunction with other drugs to manage congestive heart failure. Since hypertension can possibly lead to strokes, heart attacks, and kidney problems, this medication can help manage these health problems. It is even being used on diabetic patients suffering kidney damage.  

Side Effects:
It is possible for a patient to experience headache, dizziness, lightheadedness, fatigue, nausea, diarrhea, dry cough or blurred vision as your body responds to the medication. If these effects do not go away and remain persistent you should contact your physician or pharmacist immediately.

Mechanisms: In humans this medication has been found to inhibit angiotensin converting enzyme (ACE), which prevents it from catalyzing the reaction that converts angiotensin I to the vasoconstrictor substance, angiotensin II, which in turn is involved in aldosterone secretion. Therefore, inhibition of ACE eventually leads to suppression of renin-angiotensin-aldosterone system, which leads to reduction of hypertension and prevention of heart failure.

References: www.Rxlist.com and www.WebMD.com